Daniel Spitz, MD Co-Authors Research Study on PI3K Inhibitor Buparlisib

Fort Myers, Fla., Nov. 21, 2019 — Medical Oncologist Daniel Spitz, MD, who practices at the Florida Cancer Specialists (FCS) location in West Palm Beach, was a co-author of a new study evaluating the efficacy of buparlisib, an oral inhibitor drug of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases, which is one of the most promising new classes of potential drug targets.

Daniel-Spitz-MDAccording to an article published by PubMed Centralâ in the U.S. National Institutes of Health’s National Library of Medicine, “The phosphoinositide 3-kinase (PI3K) pathway, a critical signal transduction system linking oncogenes and multiple receptor classes to many essential cellular functions, is perhaps the most commonly activated signaling pathway in human cancer.” Because it is so common, there is a lot of research focused on developing cancer therapies that interrupt or block this pathway, thus inhibiting tumor growth.

In this Phase 2 study, patients with either solid or hematologic malignancies with PI3K pathway activation and progression on or after standard treatment received buparlisib (100 mg once daily). There were 146 patients enrolled in the study, with colorectal, sarcoma and ovarian tumor types. The goal of the study was to determine whether treatment with buparlisib monotherapy demonstrated sufficient efficacy in PI3K pathway-activated tumors to warrant further study. To evaluate, the researchers assessed clinical benefit response or stabilized disease ≥ (at or longer than) 16 weeks.

Dr. Spitz and his co-authors concluded, “Buparlisib was well tolerated, however efficacy was limited despite selection of PI3K pathway aberrations. Future studies may provide insight into buparlisib efficacy by refining the molecular selection of different tumor types.”

To read the full study: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27251&path[]=88220

Additional resource: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142564/

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